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MUSCLE-FUN PROJECT
MECHANISMS OF MUSCLE FUNCTION: FATIGUE AND OXIDATIVE STRESS

2011 - 2015

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The aim of this project was to discover the important factors and mechanisms that can affect the functionality of the uremic skeletal muscle and its direct or indirect implications in the extreme fatigue and weakness experienced by those suffering from chronic renal failure.

Through the implementation of this project our faculty has carried out:

  • The support of two PhD theses, Dr. Mitrou Georgia and Dr. Poulianiti Konstantina.

  • The publication of two free to access e-books, the first being “Muscle fatigue and muscle weakness: what we know and what we wish we did”, by Karatzaferi C. and Chase B.P. (2013), and the second being “Manual for the physical assessment of athletes” by Karatzaferi C., et al. (2015).

  • A large number of peer-reviewed articles.

Muscle-Fun Project Mechanisms of Muscle Function: Fatigue and Oxidative Stress: Research

PUBLICATIONS

MANUALS

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SAKKAS ET AL. (2015). MANUAL FOR THE ASSESSMENT OF SPECIAL POPULATIONS.

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KARATZAFERI, C. & CHASE, B.P. (2013). MUSCLE FATIGUE AND MUSCLE WEAKNESS: WHAT WE KNOW AND WHAT WE WISHED WE DID.

Muscle-Fun Project Mechanisms of Muscle Function: Fatigue and Oxidative Stress: Research

PUBLISHED WORK BY OUR FACULTY IN THIS PROJECT

April 2019

EVIDENCE OF BLOOD AND MUSCLE REDOX STATUS IMBALANCE IN EXPERIMENTALLY INDUCED RENAL INSUFFICIENCY IN A RABBIT MODEL

KP Poulianiti, A Karioti, A Kaltsatou, GI Mitrou, Y Koutedakis, K Tepetes , G Christodoulidis, G Giakas, MD Maridaki, I Stefanidis, AZ Jamurtas,  GK Sakkas and C Karatzaferi (2019) Evidence of Blood and Muscle Redox Status Imbalance in Experimentally Induced Renal Insufficiency in a Rabbit Model. Oxidative Medicine and Cellular Longevity Volume 2019, Article ID 8219283, 1-14

January 2019

EVIDENCE OF FUNCTIONAL DEFICITS AT THE SINGLE MUSCLE FIBER LEVEL IN EXPERIMENTALLY-INDUCED RENAL INSUFFICIENCY

Mitrou GI, Sakkas GK, Poulianiti KP, Karioti A, Tepetes K, Christodoulidis G, Giakas G, Stefanidis I, Geeves MA, Koutedakis Y, Karatzaferi C (2019). Evidence of functional deficits at the single muscle fiber level in experimentally-induced renal insufficiency (2019) Journal of Biomechanics, 82:259-265

March 2017

FUNCTIONAL RESPONSES OF UREMIC SINGLE SKELETAL MUSCLE FIBERS TO REDOX IMBALANCES

Mitrou GI, Poulianiti KP, Koutedakis Y, Jamurtas AZ, Maridaki MD, Stefanidis I, Sakkas GK, Karatzaferi C (2017) Functional responses of uremic single skeletal muscle fibers to redox imbalances. Hippokratia 21(1):3

December 2017

MODULATORS OF ACTIN-MYOSIN DISSOCIATION: BASIS FOR MUSCLE TYPE FUNCTIONAL DIFFERENCES DURING FATIGUE

Christina Karatzaferi, Nancy Adamek and Michael A. Geeves (2017) Modulators of actin-myosin dissociation: basis for muscle type functional differences during fatigue. Am J Physiol Cell 313: C644-C654.

2016

REDOX STATUS IN CHRONIC KIDNEY DISEASE: A SYSTEMATIC REVIEW

Poulianiti KP, Kaltsatou A, Mitrou GI, Jamurtas AJ, Koutedakis Y, Maridaki M, Stefanidis I, Sakkas GK, Karatzaferi C. Redox Status in Chronic Kidney Disease: A Systematic Review. OXID MED CELL LONGEV. 2016;2016:8598253. REVIEW. [IF 4.492]

January 2016

SKELETAL MUSCLE ATROPHY: DISEASE-INDUCED MECHANISMS MAY MASK DISUSE ATROPHY

Malavaki, C.J., Sakkas, G.K., Mitrou, G.I. et al. Skeletal muscle atrophy: disease-induced mechanisms may mask disuse atrophy. J Muscle Res Cell Motil 36, 405–421 (2015). https://doi.org/10.1007/s10974-015-9439-8

April 2015

UREMIC MYOPATHY: IS OXIDATIVE STRESS IMPLICATED IN MUSCLE DYSFUNCTION IN UREMIA?

Kaltsatou A, Sakkas GK, Poulianiti KP, Koutedakis Y, Tepetes K, Christodoulidis G, Stefanidis I, Karatzaferi C. Uremic Myopathy: is Oxidative Stress Implicated in muscle dysfunctional in Uremia? FRONT PHYSIOL. 2015 MAR 30;6:102. doi: 10.3389/FPHYS.2015.00102. ecollection 2015. REVIEW. PUBMED PMID: 25870564; PUBMED CENTRAL PMCID: PMC4378187.

Muscle-Fun Project Mechanisms of Muscle Function: Fatigue and Oxidative Stress: Publications

Funded by:

ESF-NSRF – Thales: MuscleFun Project-MIS 377260

http://www.pe-uth.gr/musclefun/index.php?lang=el

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Muscle-Fun Project Mechanisms of Muscle Function: Fatigue and Oxidative Stress: Image
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